SiGNa Chemistry: Reactions

Classic Method

Radical carbon-bond forming reactions (i.e. Wurtz reaction, acyloin condensation, etc.) are fundamental to organic synthesis. The majority of carbon-centered radicals undergo dimerization but these reactions are usually not atom economical or chemically selective increasing the costs for synthesis.

Classic #1
Classic #2

Benzyl Chloride Reduction

Acyloin Condensation

Problems

Requires substantial excess of starting materials and reagents
Separation of desired reaction products from side-products are difficult
Variations in and handling of alkali metal dispersions
Selectivity towards desired products are limited

SiGNa's Method

Carbon bond formations with SiGNa materials are able to be performed in both atom and process efficient syntheses in turn reducing cost to the end-user. The reaction conditions afford much cleaner products, safer reactive species, and milder conditions.

C-C #1
C-C #2
C-C #3

Benzyl Chloride Reduction

Diethyl Glutarate Condensation

Diethyl Malonate Acylation

Benefits

Provides a smooth solution process at room temperature
Can be performed in either batch or continuous-flow reactor setup
Enhanced selectivity and kinetics of reaction
By-products and salts removed through binding to SiGNa material

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